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CRAMP (140-173) (mouse) (trifluoroacetate salt)
CRAMP (140-173) (mouse) (trifluoroacetate salt)
品牌： Cayman
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对比
咨询分子式：
C178H302N50O46 • XCF3COOH
分子量：
3878.7
产品介绍
产品介绍
产品信息
简单描述
Cathelicidin-related antimicrobial peptide (CRAMP) (140-173) is a 34-amino acid peptide derivative of the 38-amino acid antimicrobial peptide CRAMP.1,2 Mature CRAMP is formed from cleavage of the full-length peptide by cathepsin G.3,4 CRAMP (140-173) (1 µg/ml) is active against K. pneumoniae in vitro.1 It decreases neutrophil infiltration of colonic epithelial and luminal surfaces in a porcine model of colitis when administered at a dose of 10 mg/kg.5 Ileal administration of CRAMP (140-173) (10 mg/kg) decreases disease severity and cecal bacterial burden and increases survival in a mouse model of C. difficile infection.6 However, intra-articular administration of CRAMP (140-173) (10 µl of 25 µM) also increases disease severity and induces synovitis in a mouse model of surgery-induced osteoarthritis.7WARNING This product is not for human or veterinary use.
商品描述
An antimicrobial peptide
分子量
3878.7
纯度
≥95%
产品类型
Biochemicals/Antibiotics/Peptides
背景
别名
Synonyms:Cathelicidin-related Antimicrobial Peptide Cathelin-related Antimicrobial Peptide mCRAMP
研究领域
Immunology & Inflammation/Arthritis (Non-Autoimmune)/Gastric Disease/Innate Immunity,Infectious Disease/Bacterial Diseases/Pneumonia
结构式
[H]NCC(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(NCC(NCC(N[C@@H](CCC(O)
分子式
C178H302N50O46 • XCF3COOH
制备和贮存
保存
≥ 4 years
溶解方法
Methanol: Soluble
Water: Soluble
保存方式
-20°C
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