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CRTC2, NT (CRTC2, TORC2, CREB-regulated transcription coactivator 2, Transducer of regulated cAMP response element-binding protein 2)


品牌: MyBioSource








反应种属:
Human
Human
实验应用:
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
产品介绍
产品信息
纯化方式
Affinity Purified
Purified by Protein A affinity chromatography.

抗原名称
CREB-regulated transcription coactivator 2

免疫原
CRTC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 93-123 amino acids from the N-terminal region of human CRTC2.

商品描述
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).

形式
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

产品类型
Polyclonal

应用
实验应用
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)

反应种属
Human

背景
别名
Anti -CRTC2, NT (CRTC2, TORC2, CREB-regulated transcription coactivator 2, Transducer of regulated cAMP response element-binding protein 2)

制备和贮存
保存方式
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
数据库链接
NCBI
200186

UniProt ID
Q53ET0
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