BD Transduction Laboratories™ Purified Mouse Anti-CtBP2

CtBP2

Mouse IgG1

Mouse CtBP2 aa. 361-445

Transcriptional repression is critical for genetic regulation of many cellular  proteins, and involves either a transcription regulator that has an intrinsic repressor domain, or a transcription regulator that contains a binding site in the regulatory domain where a co-repressor can bind.  C-terminal binding proteins (CtBP1 and CtBP2) are a class of co-repressors that interact with a subset of transcription factors through a PLDLSL sequence motif.  CtBP1 and CtBP2 are 80% homologous, and both are expressed at high levels in embryonic tissues.  However, CtBP1 is expressed higher in adult tissues, and is more widely expressed in embryonic and adult tissues.  Both CtBP1 and CtBP2 bind the δEF1 zinc finger-homeodomain transcription factor, and enhance transcriptional repression via interaction with the PLDLSL-sequence in δEF1.  CtBP1 and CtBP2 bind other zinc finger transcription factors, including Kheper and BKLF.  In addition, CtBP2 interacts with other transcription factors, such as hFOG-2, Evi-1, AREB6, and ZEB.  Thus, CtBP1 and CtBP2 may be important co-repressors for a variety of transcriptional factors. This antibody is routinely tested by western blot analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

16/CtBP2 Transcriptional repression is critical for genetic regulation of many cellular  proteins, and involves either a transcription regulator that has an intrinsic repressor domain, or a transcription regulator that contains a binding site in the regulatory domain where a co-repressor can bind.  C-terminal binding proteins (CtBP1 and CtBP2) are a class of co-repressors that interact with a subset of transcription factors through a PLDLSL sequence motif.  CtBP1 and CtBP2 are 80% homologous, and both are expressed at high levels in embryonic tissues.  However, CtBP1 is expressed higher in adult tissues, and is more widely expressed in embryonic and adult tissues.  Both CtBP1 and CtBP2 bind the δEF1 zinc finger-homeodomain transcription factor, and enhance transcriptional repression via interaction with the PLDLSL-sequence in δEF1.  CtBP1 and CtBP2 bind other zinc finger transcription factors, including Kheper and BKLF.  In addition, CtBP2 interacts with other transcription factors, such as hFOG-2, Evi-1, AREB6, and ZEB.  Thus, CtBP1 and CtBP2 may be important co-repressors for a variety of transcriptional factors. This antibody is routinely tested by western blot analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

Mouse IgG1

克隆 16/CtBP2 (RUO)

250 µg/ml

Western blot (Routinely Tested), Immunofluorescence (Tested During Development)

Mouse (QC Testing), Human,Rat,Dog (Tested in Development)

CtBP2

C-Terminal Binding Protein-2

Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.

研发参考(5) 1. Furusawa T, Moribe H, Kondoh H, Higashi Y. Identification of CtBP1 and CtBP2 as corepressors of zinc finger-homeodomain factor deltaEF1. Mol Cell Biol. 1999; 19(12):8581-8590. (Biology). 2. Hildebrand JD, Soriano P. Overlapping and unique roles for C-terminal binding protein 1 (CtBP1) and CtBP2 during mouse development. Mol Cell Biol. 2002; 22(15):5296-5307. (Biology: Immunohistochemistry, Western blot). 3. Katsanis N, Fisher EM. A novel C-terminal binding protein (CTBP2) is closely related to CTBP1, an adenovirus E1A-binding protein, and maps to human chromosome 21q21.3. Genomics. 1998; 47(2):294-299. (Biology). 4. Muraoka O, Ichikawa H, Shi H. Kheper, a novel ZFH/deltaEF1 family member, regulates the development of the neuroectoderm of zebrafish (Danio rerio). Dev Biol. 2000; 228(1):29-40. (Biology). 5. Turner J, Crossley M. Cloning and characterization of mCtBP2, a co-repressor that associates with basic Kruppel-like factor and other mammalian transcriptional regulators. EMBO J. 1998; 17(17):5129-5140. (Biology).