

产品介绍
产品介绍
产品信息
荧光素标记
抗原名称
CtIP

来源纯化
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human CtIP protein.

宿主
Rabbit

商品描述
Product Usage Information
Application | Dilution |
---|---|
Western Blotting | 1:1000 |

同种型
Rabbit IgG

分子量
110

研究领域
癌症,细胞生物学,神经科学

应用
反应种属
Human,Monkey,

目标/特异性
Specificity/Sensitivity
CtIP (D76F7) Rabbit mAb recognizes endogenous levels of total CtIP protein.
Species Reactivity:
Human, Monkey

敏感性
Endogenous

背景
背景
DNA damage checkpoints are critical for regulated repair of damaged DNA and genome maintenance. CtIP/RBBP8 (CtBP-interacting protein), initially characterized as a binding partner for the trancription factor CtBP, has emerged as a regulator of both cell cycle progression and repair of DNA double strand breaks (DSB). Along with the DSB-sensing MRN complex (MRE11-RAD50-NBS1), CtIP functions in the generation of single stranded DNA at DSBs, a process required for signaling to DNA repair machinery (reviewed in 1). CtIP is thought to be critical in the transition between sensing of DSBs and repair by homologous recombination (HR) (2,3).In addition to HR, DSBs can also be repaired through nonhomologous end joining (NHEJ), and CtIP has been shown to have a role in signaling to the NHEJ pathway independently of its function in DSB end resection (4).CtIP is also involved in cellular tolerence of topoisomerase inhibitors camptothecin and etoposide, which are used to treat cancer through their ability to introduce DSBs in cycling cells (5).
1.You, Z. and Bailis, J.M. (2010) Trends Cell Biol 20, 402-9.
2.You, Z. et al. (2009) Mol Cell 36, 954-69.
3.Eid, W. et al. (2010) EMBO Rep 11, 962-8.
4.Quennet, V. et al. (2010) Nucleic Acids Res, Epub ahead of print.
5.Nakamura, K. et al. (2010) PLoS Genet 6, e1000828.

研究领域
癌症,细胞生物学,神经科学
翻译后修饰
unmodified

制备和贮存
保存方式
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
数据库链接
Entrez-Gene ID
5932

UniProt ID
Q99708

参考图片
Western blot analysis of extracts from various cell lines using CtIP (D76F7) Rabbit mAb.
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