全部商品分类首页
CX546
.jpg)
1/2
用小程序，查商品更便捷
产品介绍
产品介绍
产品信息
商品描述
CX546 is an AMPA receptor potentiator and GluR activator. It appears to function by specifically binding to, and therefore destabilizing, agonist bound non-desensitized receptors. AMPA is a transmembrane glutamate receptor composed of the subunits GluR-1,2,3,4.
分子量
247.29
纯度
98%
可溶性
Ethanol : 100 mg/mL (404.38 mM; Need ultrasonic)
外观
white to off-white solid
In vitro(体外研究)
in contrast to cyclothiazide or IDRA 21, the Ampakine CX546 binds specifically to the agonist bound nondesensitized receptor, most likely acting by destabilizing the desensitized receptor conformation. In binding tests, CX546 caused an approximately 2-fold increase in the affinity for radiolabeled agonists, whereas CX516 was ineffective.
In vivo(体内研究)
Intraperitoneal injections of CX546 increased hippocampal BDNF mRNA levels in aged rats and middle-aged mice . Administration of the positive modulator of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptors (AMPAR), CX546, during the conditioning phase only, improved the disrupted LI in mGluR5 knockout mice and facilitated LI in control C57BL/6J mice, given extended number of conditioning trails (four conditioning stimulus-unconditioned stimulus) .
背景
别名
CX 546
分子式
C14H17NO3
CAS号
215923-54-9
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
声明 ：本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。