CXCL9/MIG (E7X3P) Rabbit mAb

C-X-C motif chemokine ligand 9 (CXCL9, MIG) is a soluble chemokine expressed by multiple cell types, such as endothelial cells, monocytes, and tumor cells. The expression of CXCL9 is upregulated in response to proinflammatory cytokines, such as IFN-γ and TNF-α. (1,2). CXCL9 binds to CXCR3, a GPCR that is expressed on the surface of multiple populations of immune cells, particularly exclusively activated T lymphocytes (3). Binding of CXCL9 to CXCR3 promotes T cell chemotaxis and infiltration into sites of inflammation that form in settings such as viral infection and tumorigenesis (4-6). Research studies have demonstrated production of CXCL9 by tumor cells mediates tumor suppression through the recruitment of tumor antigen-specific T cells (7). 1.Shin, S.Y. et al. (2010) J Biol Chem 285, 30731-40. 2.Hiroi, M. and Ohmori, Y. (2003) Biochem J 376, 393-402. 3.Loetscher, M. et al. (1996) J Exp Med 184, 963-9. 4.Tensen, C.P. et al. (1999) J Invest Dermatol 112, 716-22. 5.Han, K. et al. (2020) Am J Respir Cell Mol Biol, doi: 10.1165/rcmb.2020-0354OC. 6.Russo, E. et al. (2020) J Leukoc Biol 108, 673-685. 7.Gorbachev, A.V. et al. (2007) J Immunol 178, 2278-86.