Cyclosomatostatin (1 mg)

122080

FWKT

(Modifications: Phe-1 = Aminoheptanoyl-Phe, Trp-1 = DTrp, Thr-4 = Bn-Thr)

Non-selective sst antagonist

779.98

Non-selective somatostatin (sst) receptor antagonist. Blocks the effects of sst on airway β-adrenergic function, CRF-induced suppression of gastric empyting, modulation of ACh release and growth hormone, insulin and glucagon release. Reported to act as an sst receptor agonist in human neuroblastoma cell line SH-SY5Y.

≥95% (HPLC)

Soluble to 1 mg/ml in 20% ethanol / water

Cyclo-(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[BZL])

C[C@@H](OCC1=CC=CC=C1)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=CC

C₄₄H₅₇N₇O₆

84211-54-1