Cystathionine gamma-Lyase (D4E9J) Rabbit mAb

Cystathionine γ-lyase (CGL) is an enzyme in the transsulfuration pathway, a route in the metabolism of sulfur-containing amino acids (1). This enzyme regulates local vasodilation and blood pressure by generating hydrogen sulfide (H2S) as a physiological signaling molecule (2). A rodent model of sleep apnea showed that H2S production by cystathionine γ-lyase in the carotid body triggers hypertension in rodents during intermittent hypoxia, suggesting that inhibition of this enzyme may prevent the hypertension associated with sleep apnea (3). In addition, dietary restriction of sulfur-containing amino acids upregulates hepatic cystathionine γ-lyase expression in mice, leading to elevated production of H2S and protection from hepatic ischemia perfusion injury, indicating that this enzyme is critical for the benefits of dietary restriction (4). 1.Chiku, T. et al. (2009) J Biol Chem 284, 11601-12. 2.Yang, G. et al. (2008) Science 322, 587-90. 3.Yuan, G. et al. (2016) Sci Signal 9, ra80. 4.Hine, C. et al. (2015) Cell 160, 132-44.