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CYTOKERATIN 5 (KRT5)
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产品详细信息
Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.
靶标信息
Cytokeratin pan is part of a subfamily of intermediate filament proteins that are characterized by remarkable biochemical diversity, and represented in human epithelial tissues by at least 20 different polypeptides. Cytokeratins range in molecular weight between 40 kDa- 68 kDa, and an isoelectric pH between 4.9-7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays. The composition of cytokeratin pairs vary with the epithelial cell type, stage of differentiation, cellular growth environment, and disease state. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 58 kDa cytokeratin; CK-5; Cytokeratin-5; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; K5; keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5, type II; Keratin, type II cytoskeletal 5; Keratin-5; Type-II keratin Kb5
基因别名: CK5; DDD; DDD1; EBS2; K5; KRT5; KRT5A
UniProt ID:(Human) P13647
Entrez Gene ID:(Human) 3852
参考图片
Immunohistochemistry (Paraffin) analysis performed in formalin fixed, paraffin-embedded human prostate carcinoma using Cytokeratin 5 (KRT5) Monoclonal Antibody (Product # 3852-MSM4-P1ABX).
Immunohistochemistry (Paraffin) analysis performed in formalin fixed, paraffin-embedded human prostate carcinoma using Cytokeratin 5 (KRT5) Monoclonal Antibody (Product # 3852-MSM4-P1ABX).
Immunohistochemistry (Paraffin) analysis performed in formalin fixed, paraffin-embedded human cervical carcinoma using Cytokeratin 5 (KRT5) Monoclonal Antibody (Product # 3852-MSM4-P1ABX).
Immunohistochemistry (Paraffin) analysis performed in formalin fixed, paraffin-embedded human pancreas using Cytokeratin 5 (KRT5) Monoclonal Antibody (Product # 3852-MSM4-P1ABX).
Analysis of Protein Array containing more than 19,000 full-length human proteins Cytokeratin 5 (KRT5) Monoclonal Antibody (Product # 3852-MSM4-P1ABX). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
SDS-PAGE Analyis Purified Cytokeratin 5 (KRT5) Monoclonal Antibody (Product # 3852-MSM4-P1ABX). Confirmation of Purity and Integrity of Antibody.