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产品信息
商品描述
D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.
分子量
642.09
纯度
98%
可溶性
DMSO : ≥ 43.33 mg/mL (67.48 mM) ；
Ethanol : 16.67 mg/mL (25.96 mM)
Ethanol : 16.67 mg/mL (25.96 mM)
外观
oil
In vitro(体外研究)
Replacement of DSPC by unsaturated PCs and DLin-MC3-DMA by the related lipid DLin-KC2-DMA resulted in highly potent transfection reagents for HeLa cells in vitro.
In vivo(体内研究)
Lipid nanoparticles (LNPs) containing distearoylphosphatidlycholine (DSPC), and ionizableamino-lipids such as dilinoleylmethyl-4-dimethylaminobutyrate (DLin-MC3-DMA) are potent siRNA delivery vehicles in vivo. LNP-siRNA systems optimize to achieve maximum gene silencing potency in hepatocytesfollowing IV administration in mice contain DLin-MC3-DMA (MC3), DSPC, cholesterol and a polyethyleneglycol (PEG)-lipid at mole ratios of 50/10/38.5/1.5. DLin-MC3-DMA exhibits an optimized pKa value that leads to dramatically enhanced potency.
背景
分子式
C43H79NO2
CAS号
1224606-06-7
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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