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Dacarbazine
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产品介绍
产品介绍
产品信息
抗原名称
DNA polymerase beta
商品描述
Dacarbazine(DTIC-Dome) is an antineoplastic chemotherapy drug used in the treatment of various cancers, among them malignant melanoma, Hodgkin lymphoma, sarcoma, and islet cell carcinoma of the pancreas.
分子量
182.18
纯度
＞98%
可溶性
DMSO : 6.42 mg/mL (35.24 mM; Need ultrasonic and warming)
外观
微黄色结晶或粉末
In vitro(体外研究)
Treatment of Dacarbazine sensitizes melanomas to lysis of peptide-specific CTL and it is is mediated through Fas-independent pathway.
In vivo(体内研究)
Treatment of combination of Axitinib and DTIC demonstrates significant antitumor activity against melanoma flank xenografts, reduces tumor cell proliferation and decreases the area of tumor necrosis and increases apoptosis. It also reduces meta-tasis-related factors and prolongs lifespan in mice.
背景
别名
达卡巴嗪；Imidazole Carboxamide
分子式
C6H10N6O
CAS号
4342-03-4
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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