DCPIB (10 mg)

10071166

Blocker of VRAC/I_{Cl, swell}

427.37

4-[(2-Butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]butanoic acid

Potent, selective blocker of the volume-sensitive anion channel (VSAC) in rat pancreatic β-cells (IC₅₀ ~ 2 μM) and I_Cl,swell in various cardiovascular tissues (IC₅₀ = 4.1 μM in CPAE cells); blockade is voltage-independent. Displays minimal inhibition of other Cl^- and K⁺ currents (< 10% inhibition at 10 μM). Inhibits glucose-stimulated insulin secretion in intact β-cells via VSAC inhibition and indirect K_ATP channel activation. Reverses cell swelling-induced action potential duration shortening in atrial myocytes and inhibits astroglial swelling in vitro.

≥98% (HPLC)

Soluble to 100 mM in ethanol

SN-401

CCCCC1(CC2=C(C1=O)C(Cl)=C(Cl)C(OCCCC(O)=O)=C2)C1CCCC1

C₂₂H₂₈Cl₂O₄

82749-70-0