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产品介绍
产品介绍
产品信息
抗原名称
TGF-beta_Smad
序列号
H-Thr-Ser-Leu-Asp-Ala-Ser-Ile-Ile-Trp-Ala-Met-Met-Gln-Asn-OH
商品描述
Disitertide(P144)是TGF-β1的抑制剂。
分子量
1694.84
纯度
95%
可溶性
DMSO : 50 mg/mL (29.50 mM; Need ultrasonic)
In vitro(体外研究)
Disitertide (P144) prevents TGF-β1-dependent inhibition of MV1Lu proliferation in vitro and markedly reduces binding of TGF-β1 to its receptors. Disitertide blocks TGF-β1-dependent stimulation of a reporter gene under the control of human α2(I) collagen promoter.
In vivo(体内研究)
Treatment with Disitertide at low doses causes a significant inhibition of HSC activation and a marked reduction in liver fibrosis in a rat model of chronic exposure to CCl4. A dose as low as 70 μg of the 15-mer peptide Disitertide, given to rats (300 g body weight) on alternate days, decreases fibrogenesis significantly during chronic exposure to CCl4.
来源（爱必信）
Synthetic
背景
别名
地司特泰；TGF-β1抑制剂
分子式
C70H110N17O24S2F3
CAS号
272105-42-7
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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