PSD95 (7E3) Mouse mAb

Postsynaptic Density protein 95 (PSD95) is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. These family members consist of an amino-terminal variable segment followed by three PDZ domains, an SH3 domain, and an inactive guanylate kinase (GK) domain. PSD95 is a scaffolding protein involved in the assembly and function of the postsynaptic density complex (1-2). PSD95 participates in synaptic targeting of AMPA receptors through an indirect manner involving stargazin and related transmembrane AMPA receptor regulatory proteins (TARPs) (3). It is implicated in experience-dependent plasticity and plays an indispensable role in learning (4). Mutations in PSD95 are associated with autism (5). 1.Cao, J. et al. (2005) J. Cell Biol 168, 117-26. 2.Chetkovich, D.M. et al. (2002) J. Neurosci. 22, 6415-25. 3.Cai, C. et al. (2006) J. Biol. Chem. 281, 4267-73. 4.Yao, W.D. et al. (2004) Neuron 41, 625-38. 5.Cline, H. (2005) Curr. Biol. 15, R203-5.