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DMAP1 (HRP)
品牌： Usbiological
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对比
咨询纯度：
Purified by Protein G affinity chromatography.
反应种属：
Rabbit
产品介绍
产品介绍
产品信息
荧光素标记
HRP
抗原来源
Human
宿主
Rabbit
免疫原
Recombinant protein corresponding to aa250-300 from human DNA methyltransferase 1-associated protein 1.
产品用途
Suitable for use in ELISA. Other applications not tested.
简单描述
Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity.
同种型
IgG
克隆类别
Polyclonal
纯度
Purified by Protein G affinity chromatography.
形式
Supplied as a liquid in 0.01M PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol. Labeled with horseradish peroxidase (HRP).
应用
实验应用
E
推荐用量
Optimal dilutions to be determined by the researcher.
反应种属
Rabbit
交叉反应性
Hu
目标/特异性
Recognizes human DMAP1.
稀释度
Optimal dilutions to be determined by the researcher.
背景
别名
DNA methyltransferase 1-associated protein 1 (DNMAP1) (DNMT1-associated protein 1), DMAP1, KIAA1425
制备和贮存
保存方式
Storage_Temp:-20°C
Storage_and_Stability:Store product at 4°C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C. Aliquots are stable at -20°C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
数据库链接
UniProt ID
Q9NPF5
SwissProt
Q9NPF5
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