DNAJB6 (HRP)

Recombinant protein corresponding to aa208-326 from human DnaJ homolog subfamily B member 6 protein.

Suitable for use in ELISA. Other applications not tested.

Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Isoform B but not isoform A inhibits huntingtin aggregation. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity.

IgG

Polyclonal

Purified by Protein G affinity chromatography.

Suitable for use in ELISA. Other applications not tested.

Optimal dilutions to be determined by the researcher.

Rabbit

Hu

Recognizes human DNAJB6.

DnaJ homolog subfamily B member 6 (HHDJ1) (Heat shock protein J2) (HSJ-2) (MRJ) (MSJ-1), DNAJB6, HSJ2 MRJ MSJ1

O75190