DNMT3A (DNA-methyltransferase 3A, DNMT3A2, M.HsaIIIA)

Recombinant protein corresponding to human DNMT3A.

Suitable for use in ELISA and Western Blot. Other applications not tested.

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms.

IgG

Polyclonal

Purified by affinity chromatography.

Suitable for use in ELISA and Western Blot. Other applications not tested.

Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher.

Rabbit

Hu

Recognizes human DNMT3A.

1788

Q9Y6K1