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产品介绍
产品信息
抗原名称
DOCK2
来源纯化
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human DOCK2 protein. Antibodies are purified by protein A and peptide affinity chromatography.
宿主
Rabbit
简单描述
Polyclonal Antibody for studying DOCK2. Validated for Western Blotting, Immunoprecipitation. Highly specific and rigorously validated in-house, DOCK2 Antibody (CST #10127) is ready to ship.
商品描述
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:100 |
分子量
200
研究领域
纤维化,免疫学和肿瘤学,神经科学
应用
反应种属
Human
目标/特异性
Specificity/Sensitivity
DOCK2 Antibody recognizes endogenous levels of total DOCK2 protein.
Species Reactivity:
Human
敏感性
Endogenous
背景
背景
DOCK2 (dedicator of cytokinesis 2) is a member of the DOCK-A subfamily of guanine nucleotide exchange factors (GEFs) which function as activators of small G proteins (1,3). Expressed in leukocytes, DOCK2 activates isoforms of Rac which regulate chemotaxis as part of the immune response (1,2,4).
1.Nishihara, H. et al. (1999) Biochim Biophys Acta 1452, 179-87.
2.Fukui, Y. et al. (2001) Nature 412, 826-31.
3.Côté, J.F. and Vuori, K. (2002) J Cell Sci 115, 4901-13.
4.Kunisaki, Y. et al. (2006) J Cell Biol 174, 647-52.
研究领域
纤维化,免疫学和肿瘤学,神经科学
翻译后修饰
Unmodified
制备和贮存
保存方式
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
数据库链接
Entrez-Gene ID
1794
UniProt ID
Q92608
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