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产品信息
商品描述
Docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic Acid (22:6, n-3) (DHA), an abundant essential n-3 polyunsaturated fatty acid in the CNS, has been shown to play a major anti-inflammatory role. This compound has been reported to prevent LPS-induced dendritic cell maturation, characterized by a lack of proinflammatory cytokine production. Mechanistic studies suggest that DHA causes a decrease in GATA-3, T-bet, and RORγt, as well as an increase in p27 which is a cell cycle arresting agent. Additional research suggests that DHA also contains the ability to increase nitrite and decrease superoxide production in retinal microvascular endothelial cells. Docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic Acid (22:6, n-3) is an activator of RXR α, RAR β and RAR γ.
分子量
328.49
纯度
≥98%
可溶性
Soluble in ethanol, hexane, dichloromethane, chloroform, ethyl acetate, DMSO (100 mM), DMF (> 100 mg/ml), 0.15 M Tris-HCl (pH 8.5) (1 mg/ml), and ether. Sparingly soluble in aqueous buffers. Partly miscible in water.
外观
透明无色至淡黄色液体
IC50
L1210: IC50 = 13 nM (mouse); Cyclooxygenase-2: IC50 = 9.8 µM (sheep); Cyclooxygenase-1: IC50 = 15 µM (bovine); Cytochrome P450 19A1: IC50 = 33.2 µM (human)
背景
别名
顺式-4,7,10,13,16,19-二十二碳六烯酸
分子式
C22H32O2
CAS号
6217-54-5
EC号码
612-950-9
沸点
~446.7° C at 760 mmHg (Predicted)
MDL
MFCD00065722
PK值
pKa: 4.58
密度
0.95 g/mL
折射率
n20D 1.50-1.51
制备和贮存
保存方式
-20°C，有效期2年。
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