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产品介绍
产品介绍
产品信息
商品描述
Doxycycline is a synthetic tetracycline derivative with similar antimicrobial activity.
分子量
444.44
纯度
≥98%
可溶性
Water：630 mg/L
外观
Light yellow powder
In vitro(体外研究)
100 ng/mL-5 µg/mL Dox can significantly alter the metabolic profile of the cell, as well as reduce the proliferative rate, though the effect size depends upon the particular cell line used. Doxycycline arrests cells in G1-S phase of the cell cycle in PANC-1 cells and induces the expression of p53 and its downstream target p21. It down-regulates antiapoptotic genes and induces proapoptotic genes. Doxycycline also induces apoptosis through a Fas/Fas-ligand dependent pathway in Jurkat T lymphocytes.
In vivo(体内研究)
Doxycycline successfully reduces tumor growth in vivo (inhibited pancreatic cancer cell growth).
背景
别名
多西环素
分子式
C22H24N2O8
CAS号
564-25-0
制备和贮存
保存方式
Store at -20℃ for three years（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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