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产品介绍
产品介绍
产品信息
抗原名称
MTHFD2； MTHFD1
商品描述
DS18561882 is an orally available, selective and potent inhibitor of methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) with antitumor activity, inhibits MTHFD1 activity and can be used in the study of breast cancer.
分子量
608.63
纯度
98%
可溶性
DMSO : 80 mg/mL (131.44 mM)
外观
White to yellow powder
In vitro(体外研究)
DS18561882 (0-150 nM) gives the lowest GI50 value (140 nM) against the MDA-MB-231 cell line.
In vivo(体内研究)
DS18561882 (oral administration; 30, 100 or 300 mg/kg; twice daily) inhibits tumor growth inhibition with a dose-dependent manner, the tumor is completely inhibited (TGI: 67%) at the dose of 300 mg/kg in mice.
背景
分子式
C28H31F3N4O6S
CAS号
2227149-22-4
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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