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Dvl3 Antibody
品牌： CST
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对比
咨询分子量：
88 to 93
反应种属：
Human,Mouse,Rat,Hamster,Monkey,Mink,Bovine,
产品介绍
产品介绍
产品信息
荧光素标记
Unconjugated
抗原名称
Dvl3
来源纯化
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding the carboxy terminus of human Dvl3. The antibodies are purified by protein A and peptide affinity chromatography.
宿主
Rabbit
商品描述
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:100 |
分子量
88 to 93
研究领域
癌症,发育生物学与干细胞研究,纤维化,神经科学,
应用
反应种属
Human,Mouse,Rat,Hamster,Monkey,Mink,Bovine,
目标/特异性
Specificity/Sensitivity
Dvl3 Antibody detects endogenous levels of total Dvl3 protein. This antibody does not cross-react with Dvl2.
Species Reactivity:
Human, Mouse, Rat, Hamster, Monkey, Mink, Bovine
敏感性
Endogenous
背景
背景
Dishevelled (Dsh) proteins are important intermediates of Wnt signaling pathways. Dsh inhibits glycogen synthase kinase-3β promoting β-catenin stabilization. Dsh proteins also participate in the planar cell polarity pathway by acting through JNK (1,2). There are three Dsh homologs, Dvl1, Dvl2 and Dvl3 in mammals. Upon treatment with Wnt proteins, Dvls become hyperphosphorylated (3) and accumulate in the nucleus (4). Dvl proteins also associate with actin fibers and cytoplasmic vesicular membranes (5) and mediate endocytosis of the Fzd receptor after Wnt protein stimulation (6). Overexpression of Dvl has been reported in certain cancers (7,8).
1.Logan, C.Y. and Nusse, R. (2004) Annu. Rev. Cell Dev. Biol. 20, 781-810.
2.Boutros, M. and Mlodzik, M. (1999) Mech. Dev. 83, 27-37.
3.Lee, J.S. et al. (1999) J. Biol. Chem. 274, 21464-70.
4.Itoh, K. et al. (2005) J. Biol. 4, 3.1-3.12.
5.Capelluto, D.G. et al. (2002) Nature 419, 726-729.
6.Chen, W. et al. (2003) Science 301, 1391-1394.
7.Okino , K. et al. (2003) Oncol. Rep. 10, 1219-1223.
8.Uematsu, K. et al. (2003) Oncogene 22, 7218-7221.
研究领域
癌症,发育生物学与干细胞研究,纤维化,神经科学,
翻译后修饰
unmodified
制备和贮存
保存方式
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
数据库链接
Entrez-Gene ID
1857
UniProt ID
Q92997
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