西奥骨化醇

EB1089 is an analog of 1,25 dihydroxyvitamin D which acts as a vitamin D receptor (VDR). EB1089 is noted to reverse hypercalcemia and is a potent inhibitor of PTH-rP (parathyroid hormone-related peptide, PTHRP) in vitro. In studies utilizing a squamous cancer cell line, EB1089 was noted to reverse hypercalcemia. Additionally, EB1089 was reported to downregulate PTHRP expression in a prostate cancer cell line, C4-2 and was also noted to augment anchorage-independent cell growth in vitro. Other studies note that EB1089 inihibits the proliferation of HEp-2 cell lines and is reported that p57 has a profound role in this inhibition. Futhermore, EB1089 is also reported to be a noted mitogen of neonatal rat lung fibroblasts.

≥99%