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产品介绍
产品介绍
产品信息
抗原名称
EGFR(WT):7.92 nM, EGFR:0.218 nM
商品描述
EGFR-IN-7 is a selective and potent EGFR kinase inhibitor.
分子量
694.6
纯度
95%
可溶性
DMSO:<10mM
In vitro(体外研究)
TQB3804 displayed potent enzymatic activities for EGFRd746-750/T790M/C797S, EGFRL858R/T790M/C797S, EGFRd746-750/T790M, and EGFRL858R/T790M with IC50 of 0.46, 0.13, 0.26, and 0.19 nM respectively, and has similar enzymatic activity for EGFRWT (IC50 = 1.07) to Osimertinib.?It also showed expected anti-proliferative activity in 4 cell lines, Ba/F3 (EGFRd746-750/T790M/C797S), NCI-H1975 (EGFRd746-750/T790M/C797S), PC9 (EGFRd746-750), and A431 (EGFRWT), with IC50 of 26.8, 163, 45, and 147 nM, respectively.
背景
分子式
C32H41BrN9O2P
CAS号
2267329-76-8
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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