全部商品分类
.jpg)
1/3
用小程序，查商品更便捷
产品介绍
产品介绍
产品信息
抗原名称
IDO1
商品描述
Epacadostat (INCB024360) is a potent and selective indoleamine 2,3-dioxygenase (IDO1) inhibitor with IC50 of 10 nM. Phase 2.
分子量
438.23
纯度
>98%
可溶性
DMSO ：87 mg/mL (198.52 mM)
Ethanol ：53 mg/mL warmed (120.94 mM)
Ethanol ：53 mg/mL warmed (120.94 mM)
外观
Powder
In vitro(体外研究)
In IFN-γ–treated human HeLa cells, INCB024360 potently inhibits kynurenine production. INCB024360 also promotes T and natural killer (NK)-cell growth, increases IFN-gamma production, and reduces conversion to regulatory T (T(reg))-like cells.
In vivo(体内研究)
INCB024360 (100 mg/kg, p.o.), via IDO1 inhibition, suppresses kyn generation and tumor growth in immunocompetent, but not immunodeficient, mice. In mice bearing CT26 colon carcinoma, INCB024360 (100 mg/kg, p.o.) also inhibits the growth of IDO-expressing tumors by reducing kynurenine.
背景
别名
艾卡哚司他；INCB-024360；INCB 024360
分子式
C11H13BrFN7O4S
CAS号
1204669-58-8
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
声明 ：本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。