全部商品分类首页
ETP-46464
.jpg)
1/2
用小程序，查商品更便捷
产品介绍
产品介绍
产品信息
抗原名称
mTOR,ATR,DNA-PK,PI3Kα,ATM
商品描述
ETP-46464是一种有效的，选择性ATR抑制剂，IC50为25 nM。ETP-46464在100nM几乎完全抑制ATR活性。ETP-46464抑制PI3Kα，mTOR和DNA-PKcs蛋白的活性，IC50值分别为170，0.6和36 nM。ETP-46464能够促进复制叉停滞的破损。
分子量
470.52
纯度
98%
可溶性
DMSO ：6 mg/mL (12.75 mM)
In vitro(体外研究)
ETP-46464 shows almost full activity against ATR at 100 nM. ETP-46464 inhibits the activity of PI3Kα, mTOR and DNA-PKcs with IC50s of 170, 0.6 and 36 nM. ETP-46464 is able to promote the breakage of stalled replication forks. Exposure to ETP-46464 leads the generation of substantial amounts of DNA damage in replicating cells. 1 μM ETP-46464 abrogates the ionizing radiation-induced G2/M checkpoint and leads to the presence of micronuclei or completely fragmented nuclei in cells. ETP-46464 is particularly toxic for p53-deficient cells, which is exacerbated by replicative stress-generating conditions such as the overexpression of cyclin E.
背景
别名
ETP46464
分子式
C30H22N4O2
CAS号
1345675-02-6
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
声明 ：本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。