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InVivoMAb anti-mouse FasL (CD178)
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InVivoMAb anti-mouse FasL (CD178)

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品牌: BioXcell
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反应种属:
mouse
实验应用:
false
产品介绍
产品介绍
产品信息
克隆号
MFL3
克隆类别
单抗
浓度
Lot specific,typically between 4-11 mg/ml

Product Details

The MFL3 monoclonal antibody reacts with mouse Fas Ligand (FasL) also known as CD178, CD95 Ligand, and TNFSF6. FasL is a 40 kDa type II transmembrane glycoprotein and a member of the TNF superfamily. FasL is expressed on activated T cells and in spleen, testis, and eye. Upon binding to its receptor CD95 (Fas) FasL induces apoptotic cell death to maintain peripheral tolerance. Some tumors over-express FasL and induce the apoptosis of infiltrating lymphocytes, allowing the tumor to escape the effects of an immune response. CD178/CD95 interactions are also thought to play a role in the proliferation of CD8+ cells and neutrophil extravasation, chemotaxis and survival. The MFL3 antibody has been reported to block CD178/CD95 induced apoptosis.

Specifications

Isotype Armenian hamster IgG
Recommended Isotype Control(s)InVivoMAb polyclonal Armenian hamster IgG
Recommended Dilution BufferInVivoPure pH 7.0 Dilution Buffer
Conjugation This product is unconjugated. Conjugation is available via our Antibody Conjugation Services.
Immunogen BHK cells expressing B6 mouse FasL
Reported Applicationsin vivo FasL blockade
In vitro FasL blockade
Functional assay
Immunohistochemistry (paraffin)
Flow Cytometry
Formulation PBS, pH 7.0
Contains no stabilizers or preservatives
Endotoxin <2EU/mg (<0.002EU/μg)
Determined by LAL gel clotting assay
Purity >95%
Determined by SDS-PAGE
Sterility 0.2 µm filtration
Production Purified from cell culture supernatant in an animal-free facility
Purification Protein A
RRIDAB_2819046
Molecular Weight 150 kDa
Storage The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.
组成成分
抗凋亡相关因子配体抗体
应用
实验应用
false
反应种属
mouse
背景
研究领域
Apoptosis, Cancer Biology, Immunology
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货号:
BE0319-1MG
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