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产品介绍
产品信息
商品描述
FATP1-IN-1 is a potent inhibitor of fatty acid transport protein 1 (FATP1). It effectively inhibits the activity of recombinant human or mouse acyl-CoA synthetase, which is essential for the function of FATP1. The inhibition is characterized by IC50 values of 0.046 μM for human FATP1 and 0.60 μM for mouse FATP1.
分子量
375.46
纯度
98%
可溶性
DMSO:56.2 mg/mL (149.8 mM)
In vivo(体内研究)
FATP1-IN-1 (p.o.; 10 mg/kg) treatment shows the C max , AUC and T max were 5.5 μg/mL, 36 μg h/mL and 0.33 hours, respectively, and exceeds the mouse IC 50 value of 0.22 μM without considering plasma protein binding. Animal Model: Mouse plasma [1] Dosage: 10 mg/kg Administration: P.o. Result: The C max , AUC and T max were 5.5 μg/mL, 36 μg h/mL and 0.33 hours, respectively.
背景
分子式
C18H22FN5OS
CAS号
1431945-95-7
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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