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InVivoMAb anti-human CD32 (FcγRIIA)
品牌： BioXcell
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对比
咨询反应种属：
human
来源宿主：
鼠
产品介绍
产品介绍
产品信息
宿主
鼠
克隆号
IV.3
克隆类别
单抗
Product Details
The IV.3 monoclonal antibody reacts with human CD32 also known as FcγRII and FCRII, a 40 kDa polymorphic transmembrane glycoprotein and an Ig superfamily member. CD32 is expressed on monocytes/macrophages, granulocytes, platelets and B cells. CD32 enables interaction between Fc γ RII-expressing cells and opsonized antigen or IgG-containing immune complexes. This allows CD32 to function in the activation or inhibition of immune responses including degranulation, phagocytosis, ADCC, cytokine release, and B cell proliferation. The IV.3 antibody has been shown to block the biological effects of CD32 in vitro. Additionally, IV.3 f(ab’)2 fragments have been used to block CD32 in vivo in transgenic mice expressing human CD32.Specifications
| Isotype | Mouse IgG2b |
|---|---|
| Recommended Isotype Control(s) | InVivoMAb mouse IgG2b isotype control, unknown specificity |
| Recommended Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer |
| Conjugation | This product is unconjugated. Conjugation is available via our Antibody Conjugation Services. |
| Immunogen | Human K562 leukemia cell line |
| Reported Applications | in vivo FcγRIIA blockade in humanized mice in vitro FcγRIIA blockade ELISA Flow cytometry |
| Formulation | PBS, pH 7.0 Contains no stabilizers or preservatives |
| Endotoxin | <2EU/mg (<0.002EU/μg) Determined by LAL gel clotting assay |
| Purity | >95% Determined by SDS-PAGE |
| Sterility | 0.2 µm filtration |
| Production | Purified from cell culture supernatant in an animal-free facility |
| Purification | Protein G |
| RRID | AB_2687707 |
| Molecular Weight | 150 kDa |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
组成成分
鼠抗跨膜蛋白32单克隆抗体，磷酸盐缓冲液(抗体是免疫球蛋白,属于生物大分子,无生物安全风险,不具有对人传播传染病风险)
应用
反应种属
human
背景
研究领域
Immunology
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