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产品介绍
产品介绍
产品信息
抗原名称
Ferroptosis
商品描述
Ferrostatin-1 (Fer-1)是一种有效的选择性的ferroptosis抑制剂，EC50为60 nM。
分子量
262.35
纯度
＞98%
可溶性
DMSO : 26.2 mg/mL (100 mM)
Ethanol : 26.2 mg/mL (100 mM)
Ethanol : 26.2 mg/mL (100 mM)
外观
黑色固体
In vitro(体外研究)
Ferrostatin-1 is the most potent inhibitor of erastin-induced ferroptosis in HT-1080 cells (EC50=60 nM). Ferrostatin-1 does not inhibit ERK phosphorylation or arrest the proliferation of HT-1080 cells. Ferrostatin-1 does, however, prevent erastin-induced accumulation of cytosolic and lipid ROS. Cells pretreated with 0.4 μM Ferrostatin-1 displays significantly reduce intracellular reactive oxygen species (ROS) and nitrogen species (RNS) below basal levels. Additionally, increased intracellular ROS levels are also significantly lowered below basal levels by a 0.4 µM Ferrostatin-1 pretreatment. Ferrostatin-1 treatment for 24 h does not change the expression level of i-NOS in SHSY-5Y cell when compare with vehicle (0.02 % DMSO) treated cells.
背景
别名
Fer-1
分子式
C15H22N2O2
CAS号
347174-05-4
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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