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Fidaxomicin
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产品介绍
产品介绍
产品信息
抗原名称
RNA polymerase
商品描述
Fidaxomicin, is an antibiotic that belongs to the class of macrocylic antibiotics.
分子量
1058.04
纯度
＞98%
可溶性
DMSO : ≥ 33 mg/mL (31.19 mM)
外观
White to Off-White Powder
In vitro(体外研究)
Fidaxomicin acts as a RNA polymerase inhibitor by binding to the DNA template–RNA polymerase (RNAP) complex prior to the formation of the open RNAP-DNA complex in which transcription is initiated. Therefore it will inhibit protein synthesis. As a result, apoptosis is triggered in susceptible organisms such as C. difficile.
In vivo(体内研究)
The minimum inhibitory concentration for 90% of organisms for fidaxomicin against C. difficile is 0.9978 to 2 μg/mL. Fidaxomicin is not systemically absorbed as shown by a plasma concentrations below the lower limit of quantification after single-dose or multiple-dose. In contrast, fecal concentrations of fidaxomicin are much higher and are concentration-dependent. Cmax = 2 hours; Tmax = 5.2 ng/mL; AUC = 14 ng•hr/mL. Fidaxomicin is hydrolyzed by gastric acid or intestinal microsomes into a less active metabolite (OP-1118). The cytochrome enzyme system are not involved in the metabolism of fidaxomicin.
背景
别名
非达霉素；OPT-80；PAR-101
分子式
C52H74Cl2O18
CAS号
873857-62-6
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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