FLI-06

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FLI-06

品牌： Absin

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参数

分子式：

C₂₅H₃₀N₂O₅

分子量：

438.52

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产品介绍

产品信息

抗原名称

Notch

商品描述

FLI-06 is a Notch inhibitor and the early secretory pathway inhibitor. FLI-06 disrupts the Golgi apparatus in a manner distinct from that of brefeldin A and golgicide A.

分子量

438.52

纯度

>98%

可溶性

DMSO : 43.9 mg/mL (100 mM)
Ethanol : 8.8 mg/mL (20 mM)

外观

黄色粉末

In vitro(体外研究)

In HeLa NotchΔE-eGFP cells, FLI-06 blocks Notch trafficking and processing. FLI-06 changes the maturation pattern of APP and abolishes the shedding of APPs in HEK293 cells stably expressing a mutated APP that yields robust amounts of amyloid β. FLI-06 disrupt the Golgi apparatus, and inhibits general secretion at a step before exit from the endoplasmic reticulum (ER), which is accompanied by a tubule-to-sheet morphological transition of the ER.

In vivo(体内研究)

FLI-06 (50 μM) inhibits endogenous Notch signaling in zebrafish embryos.

背景

别名

FLI06；FLI 06

分子式

C₂₅H₃₀N₂O₅

CAS号

313967-18-9

制备和贮存

保存方式

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

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货号：

abs811411-10mg

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