Fludarabine (10 mg)

657237

Purine analog; inhibits DNA synthesis

285.23

9-β-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine

Purine analog that inhibits DNA synthesis. Exhibits antiproliferative activity (IC₅₀ = 1.54 μM in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP and survivin expression. Inhibits cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in lymphocytes. Also displays anticancer activity against hematological malignancies in vivo.

≥98% (HPLC)

Soluble to 100 mM in DMSO

O[C@@H]1[C@@H](CO)O[C@@H](N3C2=NC(F)=NC(N)=C2N=C3)[C@H]1O

C₁₀H₁₂FN₅O₄

21679-14-1