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Fluvastatin
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产品介绍
产品介绍
产品信息
抗原名称
HMG-CoA reductase
商品描述
Fluvastatin is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), the enzyme that catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Human hepatocellular carcinoma cell (HCC) studies indicate that Fluvastatin induces G2/M phase arrest. In the presence of Fluvastatin, HCC cells show a decrease of Bcl-2 and procaspase-9 expression, and an increase in Bax, cleaved caspase-3, and cytochrome c. Fluvastatin is antilipemic and is used to reduce plasma cholesterol levels and prevent cardiovascular disease.
分子量
411.47
纯度
≥98%
可溶性
DMSO ： >20.6mg/mL
外观
white Powder
IC50
HMG-CoA reductase: IC50 = 8 nM
In vitro(体外研究)
Fluvastatin (XU 62320) is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), the enzyme that catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Human hepatocellular carcinoma cell (HCC) studies indicate that Fluvastatin induces G2/M phase arrest. In the presence of Fluvastatin (XU 62320), HCC cells show a decrease of Bcl-2 and procaspase-9 expression, and an increase in Bax, cleaved caspase-3, and cytochrome c. Fluvastatin (XU 62320) is antilipemic and is used to reduce plasma cholesterol levels and prevent cardiovascular disease.
Ki 数据
HMG-CoA reductase: Ki= 0.3 nM
背景
别名
氟伐他汀；XU 62320；XU-62-320
分子式
C24H26FNO4
CAS号
93957-54-1
沸点
~681.8° C at 760 (Predicted)
PK值
pKa: 4.56 (Predicted), pKb: -2.8 (Predicted)
密度
~1.2 g/cm3 (Predicted)
折射率
n20D 1.59 (Predicted)
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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