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c-Fos
c-Fos
品牌： SYSY
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对比
咨询反应种属：
Reacts with: mouse (P01101), rat (P12841), human (P01100).
Other species not tested yet.
Other species not tested yet.
来源宿主：
chicken
产品介绍
产品介绍
产品信息
宿主
chicken
免疫原
Synthetic peptide corresponding to residues near the amino terminus of rat c-Fos (UniProt Id: P12841)
产品用途
This antibody is a chimeric antibody based on the monoclonal rat antibody clone 108B5. The constant regions of the heavy and light chains have been replaced by chicken specific sequences. Therefore, the antibody can be used with standard anti-chicken secondary reagents. The antibody has been expressed in mammalian cells.
IHC: For best results, tissue sections should be stored at -20°C in cryoprotectant solution. Prolonged storage at 4°C leads to a substantial loss of signal.
IHC: For best results, tissue sections should be stored at -20°C in cryoprotectant solution. Prolonged storage at 4°C leads to a substantial loss of signal.
简单描述
50 µg purified recombinant IgY, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
同种型
IgY (λlight chain)
克隆号
Ch108B5
组成成分
细胞因子转录蛋白抗体，0.05%叠氮化钠溶液，0.05%牛血清白蛋白，磷酸盐缓冲液
应用
实验应用
WB,ICC,IHC,IHC-P
反应种属
Reacts with: mouse (P01101), rat (P12841), human (P01100).
Other species not tested yet.
Other species not tested yet.
背景
背景
The Fos gene family consists of 4 members: c-Fos, FosB, FosL1, and FosL2, also called Fos related antigen 1 and 2 (FRA1 and 2). These leucine zipper proteins can dimerize with proteins of the JUN family leading to the formation of the transcription factor complex AP1 (1).The expression of Fos proteins is rapidly and transiently induced by different extracellular stimuli such as growth factors, cytokines, neurotransmitters, polypeptide hormones, stress (2).In addition Fos proteins can be phosphorylated by ERK kinases modulating transcriptional activity, protein stability and localization (3). c-Fos is the homologue to the Finkel-Biskis-Jinkins (FBJ) murine osteosarcoma virus oncogene (4).1 ) Kovary K, Molecular and cellular biology (1992) 1211: 5015-23. 2 ) Greenberg ME, Nature () 3115985: 433-8. 3 ) Monje P, The Journal of biological chemistry (2005) 28042: 35081-4. 4 ) Müller-Ladner U, Rheumatic diseases clinics of North America (1995) 213: 675-90.
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