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c-Fos
品牌： SYSY
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对比
咨询反应种属：
Reacts with: mouse (P01101), rat (P12841), human (P01100).
Other species not tested yet.
Other species not tested yet.
来源宿主：
鼠
产品介绍
产品介绍
产品信息
宿主
鼠
免疫原
Synthetic peptide corresponding to residues near the amino terminus of rat c-Fos (UniProt Id: P12841)
产品用途
IHC: For best results tissue sections should be stored at -20°C in cryoprotectant solution. Prolonged storage at 4°C leads to a substantial loss of signal.
简单描述
100 µg purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
同种型
IgG2a (κ light chain)
克隆号
108B5H5
组成成分
鼠抗细胞因子转录蛋白单克隆抗体，磷酸盐缓冲液，牛血清白蛋白0.05%，叠氮化钠溶液0.05%（抗体是免疫球蛋白，属于生物大分子，无生物安全风险，不具有对人传播传染病风险）
应用
实验应用
WB,ICC,IHC,IHC-P,FACS
反应种属
Reacts with: mouse (P01101), rat (P12841), human (P01100).
Other species not tested yet.
Other species not tested yet.
背景
背景
The Fos gene family consists of 4 members: c-Fos, FosB, FosL1, and FosL2, also called Fos related antigen 1 and 2 (FRA1 and 2). These leucine zipper proteins can dimerize with proteins of the JUN family leading to the formation of the transcription factor complex AP1 (1).The expression of Fos proteins is rapidly and transiently induced by different extracellular stimuli such as growth factors, cytokines, neurotransmitters, polypeptide hormones, stress (2).In addition Fos proteins can be phosphorylated by ERK kinases modulating transcriptional activity, protein stability and localization (3). c-Fos is the homologue to the Finkel-Biskis-Jinkins (FBJ) murine osteosarcoma virus oncogene (4).1 ) Kovary K, Molecular and cellular biology (1992) 1211: 5015-23. 2 ) Greenberg ME, Nature () 3115985: 433-8. 3 ) Monje P, The Journal of biological chemistry (2005) 28042: 35081-4. 4 ) Müller-Ladner U, Rheumatic diseases clinics of North America (1995) 213: 675-90.
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