Fox3 (Fox-3, Fox-1 Homolog C, Hexaribonucleotide-binding Protein 3, Hrnbp3, Neuronal Nuclei, NeuN, RNA Binding Protein Fox-1 Homolog 3, RBFOX3)

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Fox3 peroxisomal 3-oxoacyl CoA thiolase

Synthetic peptide corresponding to the Fox-3 gene product, shared between the human (NP_001076044) and mouse (NP_001020102) sequences, conjugated to KLH.

Fox3 is one of a family of 3 mammalian Fox homologues. Fox was discovered in C. elegans as a gene involved in sex determination, and the name Fox is an acronym of "Feminizing locus on X". The Fox protein and its 3 mammalian homologues are all about 46kD proteins each of which includes a central highly conserved RRM type RNA recognition motif, which corresponds to a small ~70aa structure consisting of 4 beta strands and two alpha-helices. An alternate name for Fox 3 is hexaribonucleotide binding protein 3, and these proteins are believed to have a role in the regulation of mRNA splicing. Much interest has focused on Fox3 as this protein corresponds to NeuN, a neuronal nuclear antigen. NeuN antibody has become very widely used as a robust marker of neurons and neuronal stem cells. Fox3 is therefore a protein which has a funciton in RNA splicing and is expressed heavily and specifically in neuronal nuclei.

Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.

Polyclonal

Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Human, Mouse

Anti -Fox3 (Fox-3, Fox-1 Homolog C, Hexaribonucleotide-binding Protein 3, Hrnbp3, Neuronal Nuclei, NeuN, RNA Binding Protein Fox-1 Homolog 3, RBFOX3)