FoxA2 HNF3beta (D56D6) Rabbit mAb

Forkhead box protein A2 (FoxA2, also known as hepatocyte nuclear factor 3β or HNF3β) is a transcription factor that plays an important role in hepatocyte function (1). FoxA2/HNF3β is required for the activation of hepatic gluconeogenic gene expression during fasting (1). Together with the PGC-1β coactivator, FoxA2/HNF3β stimulates the expression of genes involved in fatty acid β-oxidation and, therefore, increases fatty acid metabolism (2). FoxA2/HNF3β, along with PGC-1β, also activates the expression of microsomal triacylglycerol transfer protein (MTP) and promotes VLDL secretion (2). In addition to its roles in metabolic syndromes, FoxA2/HNF3β is essential for development of the endoderm and midline structures in mouse embryos (3-5). 1.Zhang, L. et al. (2005) Cell Metab 2, 141-8. 2.Wolfrum, C. and Stoffel, M. (2006) Cell Metab 3, 99-110. 3.Levinson-Dushnik, M. and Benvenisty, N. (1997) Mol Cell Biol 17, 3817-22. 4.Weinstein, D.C. et al. (1994) Cell 78, 575-88. 5.Ang, S.L. and Rossant, J. (1994) Cell 78, 561-74.