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产品介绍
产品介绍
产品信息
抗原名称
VEGFR3 ,VEGFR1 ,VEGFR2
商品描述
Fruquintinib (HMPL-013) is a small molecule vascular endothelial growth factor receptors inhibitor.
分子量
393.39
纯度
99%
可溶性
10 mM in DMSO
外观
white powder
In vitro(体外研究)
In in vitro enzymatic and cellular assays, Fruquintinib inhibits VEGFR family kinases and suppressed VEGF/VEGFR cell signaling in human umbilical vein endothelial cell (HUVEC) and human lymphatic endothial cell (HLEC) with IC50 at low nanomolar level. Few kinases are inhibited other than VEGFRs in a panel of 253 kinases test. Fruquintinib is a highly potent inhibitor of VEGF-induced angiogenesis.
In vivo(体内研究)
Fruquintinib demonstrates favorable pharmacokinetic profile in multiple animal species, oral administration of fruquintinib strongly suppressed VEGF-induced VEGFR2 phosphorylation in the lung tissue in mice. The extent and duration of the inhibition of VEGFR2 phosphorylation correlated well with drug exposures. The strong anti-angiogenic effect resulted in robust anti-tumor efficacy in a number of human tumor xenograft models with good dose response.
背景
分子式
C21H19N3O5
CAS号
1194506-26-7
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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