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FTO
品牌： SYSY
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对比
咨询反应种属：
Reacts with: mouse (Q8BGW1), human (Q9C0B1), rat (Q2A121).
Other species not tested yet.
Other species not tested yet.
来源宿主：
rabbit
产品介绍
产品介绍
产品信息
宿主
rabbit
免疫原
Recombinant protein corresponding to AA 2 to 67 from mouse FTO (UniProt Id: Q8BGW1)
简单描述
50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
组成成分
IGG-免疫球蛋白G型抗体
应用
实验应用
WB,ICC,IHC-P
反应种属
Reacts with: mouse (Q8BGW1), human (Q9C0B1), rat (Q2A121).
Other species not tested yet.
Other species not tested yet.
目标/特异性
In human it detects exclusively isoform 1. Isoforms 2, 3 and 4 lack the N-terminus that contains the antibody epitope. In mouse and rat these isoforms lacking the N-terminus have not been described. K.D. validated
背景
背景
Fat mass and obesity-associated protein also known as alpha-ketoglutarate-dependent dioxygenase FTO is an RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs. It has been shown to act as a regulator of fat mass, adipogenesis and energy homeostasis. FTO specifically demethylates N6-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes.1 ) Jia G, Nature chemical biology (2011) 712: 885-7. 2 ) Zhou J, Nature (2015) 5267574: 591-4. 3 ) Wei J, Molecular cell (2018) 716: 973-985.e5.
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