G1/S-specific Cyclin-D1 (HRP)

Recombinant human G1/S-specific cyclin-D1 protein

Suitable for use in ELISA and Western Blot. Other applications not tested.

Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner

IgG

Polyclonal

Purified by Protein G affinity chromatography.

Suitable for use in ELISA and Western Blot. Other applications not tested.

Optimal dilutions to be determined by the researcher.

Rabbit

Hu

Human

B-cell lymphoma 1 protein BCL-1 oncogene PRAD1 oncogene CCND1 BCL1, PRAD1

P24385