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G3BP1 (E9G1M) XP ® Rabbit mAb (Alexa Fluor ® 488 Conjugate)

品牌： CST

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产品介绍

产品信息

荧光素标记

Alexa Fluor® 488

抗原名称

G3BP1

来源纯化

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val218 of human G3BP1 protein.

宿主

Rabbit

简单描述

This Cell Signaling Technology antibody is conjugated to Alexa Fluor® 488 fluorescent dye and tested in-house for direct immunofluorescent analysis in human cells. This antibody is expected to exhibit the same species cross-reactivity as the unconjugated G3BP1 (E9G1M) XP® Rabbit mAb #61559.

商品描述

Product Usage Information

Application	Dilution
Immunofluorescence (Immunocytochemistry)	1:50 - 1:400

同种型

Rabbit IgG

研究领域

RNA 调节与翻译调控

应用

反应种属

Human,Monkey,

目标/特异性

Specificity/Sensitivity

G3BP1 (E9G1M) XP Rabbit mAb (Alexa Fluor 488 Conjugate) recognizes endogenous levels of total G3BP1 protein. This antibody does not cross-react with G3BP2 protein.

Species Reactivity:

Human, Monkey

敏感性

Endogenous

背景

Ras GTPase-activating protein-binding protein 1, also known as GAP SH3 domain-binding protein 1 (G3BP1), was identified as a protein that interacts with the SH3 domain of Ras GTPase-activating protein (RasGap) (1). G3BP1 is involved in the regulation of multiple cellular processes, including mRNA decay and inhibition of translation initiation (2). Furthermore, G3BP1 is essential for the assembly of stress granules (SGs) and functions as an SG-nucleating protein (3). Research studies show that arginine demethylation of G3BP1 promotes SG assembly during oxidative stress (4). 1.Parker, F. et al. (1996) Mol Cell Biol 16, 2561-9. 2.Fischer-Kešo, R. et al. (2014) Mol Cell Biol 34, 4244-56. 3.Kedersha, N. et al. (2016) J Cell Biol 212, 845-60. 4.Tsai, W.C. et al. (2016) J Biol Chem 291, 22671-85.

研究领域

RNA 调节与翻译调控

翻译后修饰

unmodified

制备和贮存

保存方式

Supplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/ml BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze.

数据库链接

Entrez-Gene ID

10146

UniProt ID

Q13283

参考图片

Confocal immunofluorescent analysis of HeLa cells, untreated (left) or treated with sodium arsenite (500 µM, 30 min; right), using G3BP1 (E9G1M) XP® Rabbit mAb (Alexa Fluor® 488 Conjugate) (green). Actin filaments were labeled with DyLight™ 650 Phalloidin #12956 (red). Samples were mounted in ProLong® Gold Antifade Reagent with DAPI #8961 (blue).

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货号：

94496S

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询价

100ul

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