Gelsolin (D9W8Y) Rabbit mAb (BSA and Azide Free)

Gelsolin (actin-depolymerizing factor, ADF, AGEL, Brevin) is an 83 kDa protein that shares structural and functional homology to villin and adseverin/scinderin (1,2). Gelsolin plays an important role in actin filament assembly by capping and severing actin proteins in a Ca2+-dependent manner (3,4). Gelsolin is important for cellular events (e.g., membrane ruffling, chemotaxis, ciliogenesis) that require cytoskeletal remodeling (3). Accordingly, cells from gelsolin knockout mice exhibit motility defects, including a failure to ruffle in response to growth factor stimulation (5,6). In humans, defects in gelsolin have been linked to amyloidosis type 5 (AMYL5), a hereditary disease characterized by cranial neuropathy, which appears to result from gelsolin amyloid deposition (7). 1.Vitale, M.L. et al. (1991) J Cell Biol 113, 1057-67. 2.Lueck, A. et al. (1998) J Cell Sci 111 ( Pt 24), 3633-43. 3.Sun, H.Q. et al. (1999) J Biol Chem 274, 33179-82. 4.Li, G.H. et al. (2010) Med Res Rev, 32, 999-1025. 5.Azuma, T. et al. (1998) EMBO J 17, 1362-70. 6.Lu, M. et al. (1997) J Cell Biol 138, 1279-87. 7.Haltia, M. et al. (1990) Biochem Biophys Res Commun 167, 927-32.