Girdin (Girdin, Akt Phosphorylation Enhancer, APE, Coiled-coil Domain-Containing Protein 88A, G alpha-interActing Vesicle-Associated Protein, GIV, Gir

Human

Rabbit

Synthetic peptide corresponding to Internal of human Girdin.

Suitable for use in Immunohistochemistry. Other applications not tested.

Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation By similarity. Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress fibers and lamellipodia. May be involved in membrane sorting in the early endosome.

IgG

Polyclonal

Purified by immunoaffinity chromatography.

Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 0.02% sodium azide, 50% glycerol.

IHC

Immunohistochemistry: 1:50-1:100 Optimal dilutions to be determined by the researcher.

Rabbit

Hu Mo

Human Mouse

55704

Q3V6T2

Q3V6T2