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GLP-1 (7-36) amide (trifluoroacetate salt)
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产品介绍
产品介绍
产品信息
简单描述
GLP-1 (7-36) amide is a peptide hormone released from intestinal L-cells upon nutrient consumption. It binds the GLP-1 receptor (pIC50 = 8.5) in the pancreas and displays various antidiabetic effects by potentiating glucose-induced secretion of insulin from pancreatic β-cells, increasing insulin expression, inhibiting β-cell apoptosis, promoting β-cell neogenesis, reducing glucagon secretion, delaying gastric emptying, promoting satiety, and increasing peripheral glucose disposal.1WARNING This product is not for human or veterinary use.
商品描述
A GLP-1R agonist
分子量
3297.6
产品类型
Biochemicals/Peptides/Peptide Hormones/Receptor Pharmacology
背景
别名
Synonyms:Glucagon-like Peptide 1 (7-36) amide
研究领域
Cardiovascular System/Cardiovascular Diseases/Cardiomyopathy/Heart/Myocardial Contractility/Myocardial Hypertrophy/Vasculature/Vasodilation,Cell Biology/Cell Death/Apoptosis,Endocrinology & Metabolism/Hormones & Receptors/Metabolic Diseases/Diabetes/Obesity
结构式
O=C([C@H](CC1=CNC2=C1C=CC=C2)NC([C@@H](NC([C@@]([H])(NC([C@H](CC3=CC=CC=C3)NC([C@@H](NC([C@@H](NC([C
制备和贮存
保存
≥ 4 years
溶解方法
Water: 1 mg/ml
保存方式
-20°C
文献
文献
1.Donnelly, D. The structure and function of the glucagon-like peptide-1 receptor and its ligands. British Journal of Pharmacology 166(1), 27-41 (2012).
参考图片
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