全部商品分类
.jpg)
1/2
用小程序，查商品更便捷
产品介绍
产品介绍
产品信息
抗原名称
MUC-1C
商品描述
GO-203 is a D-amino acid cell-penetrating peptide inhibitor of MUC1-C dimerization and thereby its oncogenic function.
分子量
2426.77
纯度
98%
可溶性
10 mM in DMSO
外观
powder
In vitro(体外研究)
GO-203 inhibits MUC1-C homodimerization which blocks its oncogenic function. Treatment of MUC1-overexpressing SKCO-1 and Colo-205 colon cancer cells with GO-203 is associated with downregulation of the TP53-inducible glycolysis and apoptosis regulator (TIGAR) protein. GO-203 regulates AKT-S6K1-elF4A signaling in colorectal cancer cells. Targeting MUC1-C with GO-203 inhibits p-AKT in colorectal cancer cells. GO-203 treatment also results in increases in reactive oxygen species (ROS) and loss of mitochondrial transmembrane potential.
In vivo(体内研究)
GO-203 is effective in inhibiting growth and survival of MUC1-positive colorectal cancer cells in mouse xenograft models. It is also effective in xenografts models of breast, prostate, lung and certain hematologic malignancy.
背景
分子式
C87H170N52O19S2.C2HF3O2
CAS号
1222186-26-6
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
声明 ：本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。