N-Acetyl-S-farnesyl-L-cysteine (AFC)
货号: abs42022842-5mg 品牌: Absin 应用:
An inhibitor of S-farnesylcysteine methyl transferase
An inhibitor of S-farnesylcysteine methyl transferase
规格: 5mg
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价格: ¥ 1110.00

目录价: ¥1110.00

数量
- +
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概述
描述
N-Acetyl-S-farnesyl-L-cysteine is a synthetically derivatized cysteine amino acid inhibitor of S-farnesylcysteine carboxyl methyltransferase enzymes. These enzymes recognize N-Acetyl-S-farnesyl-L-cysteine as a substrate through the farnesyl moiety, and occupation of the binding site blocks processing of farnesylated proteins by the enzyme. Carboxyl methylation of farnesylated proteins is an important modification that regulates protein function. Blockade of methyltransferase processing of platelet rap1 proteins by N-Acetyl-S-farnesyl-L-cysteine leads to inhibition of platelet aggregation. N-Acetyl-S-farnesyl-L-cysteine is also described to block the cellular movement and membrane adhesion of Ras proteins by interfering with carboxyl methylation processing. N-Acetyl-S-farnesyl-L-cysteine as a substrate for isoprenylated protein methyltransferase is described to block fMet-Leu-Phe-stimulated release of superoxide radical anion in neutrophil cells. Inhibition of neutrophil chemotaxis by N-Acetyl-S-farnesyl-L-cysteine also produces suppression of inflammatory response induced by 12-O-tereadecanoyl-phorbol-13-acetate and arachidonic acid.
别名
2-acetamido-3-(3,7,11-trimethyldodeca-2,6,10-trienylsulfanyl)propanoic acid
应用
An inhibitor of S-farnesylcysteine methyl transferase
形式
Liquid
是否允许进口
允许
是否危险品
非危险品
性能
供应商
Absin
存放说明
Store at -20° C
纯度
≥98%
计算分子量
367.55
可溶性/溶解性
Soluble in ethanol (25 mg/ml), DMSO (25 mg/ml), DMF (~20 mg/ml), 0.1 M Na2CO3 (63 mg/ml), PBS (pH 7.2), and water (63 mg/ml) at 25° C.
CAS号
135304-07-3
外观
Oil
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