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产品介绍
产品介绍
产品信息
简单描述
A group I PAK inhibitor
商品描述
FRAX486 is an inhibitor of group I p21-activated kinases (PAKs; IC50s = 8.25, 39.5, and 55.3 nM for PAK1, PAK2, and PAK3, respectively).1 It is selective for group I PAKs over PAK4, a group II PAK (IC50 = 779 nM). FRAX486 (20 mg/kg) reverses decreases in the mean density of apical dendritic spines in the temporal cortex in the Fmr1-/- mouse model of fragile X syndrome. It completely abolishes audiogenic seizures, hyperactivity, and stereotypical movements in Fmr1-/- mice when administered at a dose of 30 mg/kg. FRAX486 prevents adolescent cortical dendritic spine loss and rescues prepulse inhibition deficits in a Disc1 knockdown mouse model of schizophrenia.2
分子量
513.4
纯度
≥98%
背景
结构式
ClC1=CC(Cl)=C(C2=CC3=CN=C(NC4=CC(F)=C(N5CCNCC5)C=C4)N=C3N(CC)C2=O)C=C1
分子式
C25H23Cl2FN6O
CAS号
1232030-35-1
制备和贮存
保存
≥ 4 years
溶解方法
DMF: 2 mg/ml
DMSO: 2 mg/ml
DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml
Ethanol: slight sol
保存方式
-20°C
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