NEK7 Antibody

NEK7 (NIMA-related protein kinase 7), is one of a family of serine/threonine kinases, named NEK1–NEK11, which are involved in the control of mitosis and other non-mitotic functions (1-6). NEK7 is the smallest NIMA-related kinase in mammals, and is widely expressed by many tissues (1-3). Its role in mitosis relates to centrosome enrichment and microtubule nucleation, and similar to other NIMA-related kinases, NEK7 is localized to the microtubule-organizing center (MTOC) at the time of mitotic entry (3,6). NEK7 has also been demonstrated to be essential for NLRP3 inflammasome activation by directly binding to the leucine-rich repeat (LRR) domain of NLRP3 (4-6). 1.Kandli, M. et al. (2000) Genomics 68, 187-96. 2.Belham, C. et al. (2003) J Biol Chem 278, 34897-909. 3.O'regan, L. et al. (2007) Cell Div 2, 25. 4.Shi, H. et al. (2016) Nat Immunol 17, 250-8. 5.He, Y. et al. (2016) Nature 530, 354-7. 6.Sun, Z. et al. (2020) Front Physiol 11, 606996.