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m6A
m6A
品牌： SYSY
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对比
咨询反应种属：
Reacts with: human, rat, mouse, prokaryotes, eukaryotes.
Other species not tested yet.
Other species not tested yet.
来源宿主：
rabbit
产品介绍
产品介绍
产品信息
宿主
rabbit
免疫原
N6-methyladenosine fused to BSA.
产品用途
This antibody is a chimeric antibody based on the well known monoclonal mouse antibody clone 345E11. The constant regions of the heavy and light chains have been replaced by rabbit specific sequences. Therefore, the antibody can be used with standard anti-rabbit secondary reagents. The antibody has been expressed in mammalian cells.
简单描述
100 µg purified recombinant IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
同种型
IgG1 (κ light chain)
克隆号
Rb345E11
应用
实验应用
Dot,blot,IP,MeRIP
反应种属
Reacts with: human, rat, mouse, prokaryotes, eukaryotes.
Other species not tested yet.
Other species not tested yet.
目标/特异性
Specific for N6-methyladenosine (m6A) with some cross-reactivity to m6Am
背景
背景
m6A (N6-methyladenosine) is a posttranscriptional RNA-modification found throughout all kingdoms, e.g. in vertebrate snRNAs U2, U4, U6, in viral and eukaryotic mRNAs, and in E. coli 16S rRNA.Recent studies have found that mRNA is predominately m6A modified at stop codons and long internal exons, which are conserved between mouse and human. The so-called RNA methylome probably plays an important role in in the regulation of gene expression.In E. coli Dam methylase introduces m6A modifications on the DNA level at the 5'-GATC-3' motif. This allows the cell to differentiate between the parental and the daughter strand during mismatch repair.1 ) Bringmann P, FEBS letters (1987) 2132: 309-15. 2 ) Warda AS, EMBO reports (2017) 1811: 2004-2014. 3 ) Xiang Y, Nature (2017) 5437646: 573-576. 4 ) Koziol MJ, Bio-protocol (2016) 621: . 5 ) Koziol MJ, Nature structural & molecular biology (2016) 231: 24-30.
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